New Continuous Chromatography Options

Why continuous chromagraphic processes should be explored One of the most powerful and increasingly more relied upon purification methods used in pharmaceuticals and biotechnology is chromatography. This application has also acquired added significance as regulatory bodies have required higher and higher purity and reproducibility in the new products being developed. This is especially true in the field of biologics where the use of chromagraphic methods is paramount in producing products of acceptable purity. Since starting out in its infancy as an analytical method, one of chromatography’s biggest challenges has been in scale up. As processes move out of the lab and into a production setting, the batch nature of traditional column-based systems starts showing their significant constrains. As the material to be processed becomes larger, the labor-intensive requirements of column-based chromagraphic applications have effects that increase costs and the potential for production errors and contamination. This can easily result in this section of the process becoming a significant bottleneck.